The church of the holy and renowned great-martyr Panteleimon was embellished with the contribution of Lord Alexios Komnenos, son of the purple-born Theodora, in the month of September; indiction 13, 1164, Ioannikios the monk being hegoumenos.
Inscription has been preserved on the marble architrave above the main entrance into the naos of Nerezi. It reads:
Ἐϰαλλιεϱγήθη ὁ ναὸς του ἁγίου ϰαὶ ἐνδόξου μεγαλομάϱτυϱος Παντελεήμονος ἐϰ συνδϱομῆς ϰυϱοῦ ’Αλεξίου τοῦ Κομνηνοῦ καὶ υἱοῦ τής πορφυρογεννήτης κυϱᾶς Θεοδώρας μηνί Σεπτεμβρίῳ…