The village Mokrino is mentioned in course of the boundary delimitation of the land around the church of the priest Simon Prьkja and of the land, which belonged to Laskar Siderofag and Tutko. The litigants (Hilandar Monastery and the Monastery Hagios Panteleemon on Mount Athos) were settled by the arbitration-comitee summoned by the Serbian Despot Konstantin Dragaš in 1375/1376 (i prězь Gabrь prěkim putem koi grede u Mokrane). In 1376/77 the mother of the Serbian Despots Jovan and Konstantin Dragaš, Evdokija, donated together with her sons the village of Mokrino with boundaries, summer pasture, mountain, vineyards, fruit trees, watermill, vegetable gardens, field, meadow, hunting grounds, fords, river and the land of Ljenьdin, which was added to Mokrino by the Emperor Stefan Uroš IV Dušan, to the Monastery Hagios Panteleemon on Mount Athos (Selo Mokrani sь sinoromь, sь planinomь, sь brьdomь, sь vinogradi, sь ovoštьjemь, sь vodeničьjemь, sь kipuriamy, sь poljemь, sь lugomь, sь lovišti, zь brodovi, sь rekomь, i što jestь priložilь carь Stefanь zemlju Ljenьdinovu kь Mokranomь). The Serbian Despot Jovan Dragaš and his brother Konstantin Dragaš confirmed after 1376/1377 the donation of the village Mokrino to the Monastery Hagios Panteleemon on the Holy Mount Athos (I prьvo selo Mokrane, i selište Crьkvišta, i selište Makrijevo, i selo Borisovo, i selo Zubovo, i selo Gabrovo, i selo Napodu). The vilage of Mokrino is registered in the Defters for the Nahiya Strumica in 1519 and 1573.