Died probably before August 1362. He is mentioned as κῦρ, δοῦλος of the Byzantine Emperor Andronikos III Palaiologos and Ioannes V. Palaiologos in the sources.He held the position of μέγας παπίας, 1333–1342 and 1352. He is attested as an apographeus (fiscal official) of the Byzantine Emperor Ioannes VI Kantakuzenos in 1349 and as archon at Didymoteichon in 1352. He was a monk. Probably the son of μέγας παπίας Alexios Tzamplakon. He was the brother of Asomatianos Tzamplakon, Demetrios Tzamplakon and Tornikina. His sons were Michael Kaballarios Tzamplakon and Alexios Kaballarios Tzamplakon. He was the συμπένθερος of Ioannes VI Kantakuzenos. He accused in the early summer of the year 1333 at Chalkidike Philantropenos Palaiologos Syrgiannes of a high treason before the Emperor Andronikos III. Palaiologos. He came to Constantinople in order to attend the trial with Philantropenos Palaiologos Syrgiannes. He authenticated the deed of sale of the protostrator Theodoros Dukas Palaiologos Komnenos Synadenos in December 1333. He was sent in 1342 together with Konstantinos Palaiologos by Ioannes VI. Kantakuzenos to the Serbian King Stefan Uroš IV Dušan. He was together with Konstantinos Palaiologos taken into custody by a certain Tzimpanos. Tzimpanos turned Arsenios Tzamplakon in to Alexios Apokaukos in Thessalonike. Arsenios Tzamplakon was insulted by the mob of Thessalonike as the patriarch of Ioannes VI Kantakuzenos. He was arrested and his possession was confiscated. According to the Praktikon issued in January 1342 by Michal Papylas Romanos was Ioannes Margarites the recipient of a confiscated land from Arsenios Tzamplakon located between Serres and Zichna. The possession of Ioannes Margarites at Kato Uska and Rachoba was declared exempt from the 9 nomismata tax and hereditary by the prostagma of the Byzantine Emperor Ioannes V. Palaiologos from October 1342. The former estates of Tzako [...], most probably Arsenios Tzamplakos, consisted of arable land and vineyards. The Serbian Emperor Stefan Uroš IV Dušan donated in April 1348 the former property of Arsenios Tzamplakon, which was inside the town of Chrysopolis, to the Batopedi Monastery. He drew up before December 1349 the inventory of the property of the Monastery Theotokos Psychosostria in Constantinople, which was used for chrysobull charter of the Byzantine Emperor Ioannes VI Kantakuzenos. After 1355 he was residing in the Batopedi Monastery as a monk. He bequeathed in February 1355 his patrimonial estate in Prinarion with als its area and rights, dependent peasants, abandoned land, vineyards, mills, uncultivated land and pasture, a part of land in Vela, winter pasture in Thermopotamos, annual fair of Saint Symeon in Vela and the fortification called Slanesion/Sthlanesion to the Batopedi Monastery. In May 1356 he added houses and the Church of Holy Mother of God Kamariotissa in the Kataphyge quarter at Thessalonike, his part of the patrimonial land in the mouth of the river Galikos including salty soil, some dikaia near the sea till Chenaru and a tower to the endowment, which he donated before to the Batopedi Monastery.