Mentioned in the two variants of the chrysobull charter confirming the donations of Hrelja to the Hilandar Monastery in the area of Štip and Strumica issued by the Serbian King Stefan Uroš IV Dušan and in the decision of the Protaton on Mount Athos from December 1370. Died before 1374. He appeared as κῦρ in the decision of the Protaton on Mount Athos from December 1370. He was a monk. He was the father of Konstantinos Palaiologos Laskaris, Georgios Laskaris and Leon Koteanitzes Laskaris. He donated in 1364 the village Mpresnitza to the Saint Panteleimon Monastery on Mount Athos. The monks from the Hilandar Monastery accused him of an unlawful seizure of their land (οὗ τινος δὴ χωρίου γῆ προσηνέχθη μετὰ τοῦ δηλωθέντος χρυσοβούλλου παρὰ τοῦ ἐν μοναχοῖς κῦρ Μακαρίω Λάσκαρη τοῦ Κοτεανίτζη, ὅπερ μετὰ δολιότητος διὰ τὸ κλαπῆναι καὶ τὸ χρυσόβουλλον παρὰ τῶν δηλωθέντων Ῥωσῶν, καὶ συναρπαγεῖς ὁ Λάσκαρις ἐξέδοτο καὶ πρὸς αὐτοὺς ὁ τοιοῦτος τόπος). They insisted on their claim on the grounds of a chrysobull granted to their monastery. The Protaton on Mount Athos gathered in December 1370 at the behest of the Serbian Despot Ioan Uglješa (Ioannes Unklesis) ruled the dispute over the village of Mpresnitza in favour of the Hilandar Monastery. Makarios Koteanitzes Laskaris probably possessed also the village of Sekirnik and a parcel of land (Selište Sekir’nik i komat zemlje što jestь drьžalь Laskarь Kotanicь/Selo Sěkir’nykь i zem’lja što jestь drьžalь Laskarь Kotanicь).