Mentioned in the sources between 1352 and 1360. He was designated as κὺρ. He appears as οἰκεῖος of the Serbian Emperor Stefan Uroš IV Dušan in the confirmation charter for the Monastery of Saint Anastasia near Zichna. The sources refer to him also as δοῦλος of the Serbian Empress Jelena (Helene). He held the office of Logothetes, since 1352; then of Governor of Serres (Nestegus capitaneus Seren.; Nestegus Zephalia Seren.), 1354 and finally of Megas Papias, 1360. His wife was Eudokia Nestongissa. The Serbian Emperor Stefan Uroš IV Dušan confirmed in the year 1352 that the village Ostrina belonged to the Monastery of Saint Anastasia near Zichna. He ordered Georgios Dukas Nestongos (οἰκεῖος ὁ αὐτῆ κὺρ Γεώργιος ὁ λογοθέτης) to look after the inviolability of the rights of the monastery. He (Ὀ λογοθέτης Γεώργιος Δούκας ὁ Νεστόγγος) together with his wife (Σίγνον Ευδοκίας Παλαιολογίνης τῆς Νεστογγόνισας) possessed an orchard near Serres, which was partly a dowry and partly acquired by the couple. They donated it in 1353 to Monastery of Saint John Prodromos near Serres, which owned mills in the vicinity of the orchard, for exchange of life annuity payed to them by the monastery. He together with judge Božidar and Damjan from Kotor was sent by the Serbian Emperor Stefan Uroš IV Dušan in 1354 to the papal court in Avignon. He participated in the decision of the ecclesiastical court, which was summoned by Iakobos, the Metropolitan of Serres, concerning the metochion Saint Nicholas in Kamenikaia. He signed also the document issued by Iakobos in November 1360 (ὁ δοῦλος τῆς κραταιᾶς καὶ ἁγίας ἡμῶν κυρίας καὶ δεσποίνης Δούκας ὁ Νεστόγγος ὁ μέγας παπίας).