Died in 1351. He was a commandant of the soldiers at the acropolis in Thessalonike, 1328. He held the position of the governor of Edessa (Vodena), 1350–1351 (Λυζικὸς δὲ ὁ τῆς πόλεως ἄρχων). He came from Beroia. He defended the acropolis of Thessalonike against Andronikos III Palaiologos, just after the Byzantine Emperor had conquered the town. His soldiers forced him to handover the acropolis of Thessalonike to Andronikos III Palaiologos. He deafeated the Serbian Emperor Stefan Uroš IV Dušan at Kastoria. The Byzantine Emperor Ioannes VI Kantakuzenos appointed him 1350 as governor of the town Edessa (Vodena), which was captured by the Byzantine army recently. He was injured in Edessa (Vodena) during the Serbian invasion of the town. The Serbian Emperor Stefan Uroš IV Dušan let Lyzikos’ beard to pull out as an act of revenge. Lyzikos was sent in chains to Skopje. He died on the way.